Drug Standards
Apexbio Technology LLC Montelukast Sodium 151767-02-1 10mM (in 1mL DMSO)
Montelukast Sodium (CAS 151767-02-1) is a selective reversible antagonist targeting the leukotriene D4 (LTD4) receptor It inhibits LTD4 receptor binding with Ki values of 0 52 nM in U937 cells 0 18 nM in guinea pig lung and 4 nM in sheep lung In U937 and THP-1 cell membranes Montelukast Sodium has IC50 values of 10 mM and 40 mM respectively against leukotrienes C3 and B4 In animal studies oral administration inhibits LTD4-induced bronchoconstriction with an ED50 of 0 03 mg/kg in conscious squirrel monkeys It is widely utilized in biomedical research investigating leukotriene-mediated inflammatory pathways and respiratory disorders
Cayman Chemical Methocarbamol 10g
An orally bioavailable skeletal muscle relaxant; inhibits the ability of mice to remain on a vertical ladder for 1 minute (ED50 = 15 mg/kg) and decreases forelimb grip strength by 35.9% (500 mg/kg); abolishes femoral nerve-stimulated polysynaptic reflex contractions of the cat tibialis anterior muscle and prolongs the mean refractory period of directly or indirectly stimulated skeletal muscle (200 mg/kg); inhibits human CAI over CAII (IC50s = 70 and ~80,000 μM, respectively)
Apexbio Technology LLC Boceprevir 394730-60-0 25mg
Boceprevir is an oral inhibitor targeting hepatitis C virus (HCV) NS3 protease an enzyme essential for processing viral polyproteins during HCV replication The compound binds directly and reversibly to the NS3 enzyme s active site forming a covalent adduct through its ketoamide functionality Cell-based replicon assays demonstrated that boceprevir inhibits HCV replication in cultured hepatocytes with an IC90 of approximately 350 nM In preclinical studies boceprevir exhibited favorable selectivity towards HCV NS3 relative to human neutrophil elastase Commonly boceprevir is used in research investigating HCV replication mechanisms and NS3 enzyme function as well as in antiviral combination assays involving interferon-based regimens
Cayman Chemical S-CRIZOTINIB 25MG
An MTH1 inhibitor (IC50 = 72 nM); selective for MTH1 over a panel of 456 kinases at 1 µM; induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 cancer cells at 30 µM; induces ROS production and apoptosis in the same model; inhibits proliferation in a panel of 14 cancer cell lines expressing wild-type or various mutant forms of K-Ras or p53 (IC50s = 0.52-7.4 µM); inhibits tumor growth in an SW 480 mouse xenograft model at 25 mg/kg
Sigma Aldrich Fine Chemicals Biosciences Galactose European Pharmacopoeia (EP) Reference Standard | 59-23-4 | MFCD00151230 |
Galactose European Pharmacopoeia (EP) Reference Standard | MW: 180.16 | 59-23-4 | MFCD00151230
Selleck Chemical LLC Binimetinib
Binimetinib (MEK162 ARRY-162 ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy Phase 3
Selleck Chemical LLC Eltanexor (KPT-8602) 2mg 1642300-52-4 ONO-7706ATG-016
Eltanexor (KPT-8602, ONO-7706,ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20?211?nM in 10 AML lines after 3 days exposure. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Miransertib (ARQ 092) HCl 5mg 1313883-00-9 Miransertib
Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Fostamatinib (R788) disodium S2206-1g
Fostamatinib disodium (R788 Tamatinib Fosdium) a prodrug of the active metabolite R406 is a Syk inhibitor with IC50 of 41 nM in a cell-free assay strongly inhibits Syk but not Lyn 5-fold less potent to Flt3 Phase 3
Selleck Chemical LLC Mifepristone S2606-1g
Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0 2 nM and 2 6 nM respectively Mifepristone promotes cell autophagy and apoptosis decreases Bcl-2 level and increases Beclin1 level accompanied by weakened interaction between Bcl-2 and Beclin1 Mifepristone (RU486) can be used to induce animal models of Spontaneous Abortion
eMolecules Medchem Express / N-Acetyl mesalazine-d3 / 1mg / 779715187 / HY-66008S / / 93968-79-7 / MFCD09839833 / 198.192 / C9H9NO4
Medchem Express / N-Acetyl mesalazine-d3 / 1mg / 779715187 / HY-66008S / / 93968-79-7 / MFCD09839833 / 198.192 / C9H9NO4
Medchemexpress LLC Linagliptin impurity 12 | 10mg
Linagliptin impurity 12 is an impurity of Linagliptin (HY-10284)
Cayman Chemical CefdItren PIvoxIl 100mg
A prodrug form of cefditoren; effective against systemic S. aureus, E. coli, K. pneumoniae, P. mirabilis, or S. marcescens infections in mice (ED50s = 10, 2.5, 11, 4.4, and 11 mg/kg, respectively)
Selleck Chemical LLC Plerixafor (AMD3100) 8HCl 50mg 155148-31-5 JM 3100 8HCl
Plerixafor (AMD3100, JM 3100) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent. *For Research & Development use only. Product is not intended for drug, household, or human consumption.